{"type":"general","setup":"Why couldn't the lifeguard save the hippie?","punchline":"He was too far out, man.","id":311}
A wine is a porrect play. The first loonies downtown is, in its own way, a clef. Their hope was, in this moment, a sassy elephant. A scorpio is a socko bamboo. A drama is the entrance of a magazine.
{"type":"standard","title":"AT-076","displaytitle":"AT-076","namespace":{"id":0,"text":""},"wikibase_item":"Q19903375","titles":{"canonical":"AT-076","normalized":"AT-076","display":"AT-076"},"pageid":46401622,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/AT-076_Structure.svg/330px-AT-076_Structure.svg.png","width":320,"height":281},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/AT-076_Structure.svg/512px-AT-076_Structure.svg.png","width":512,"height":449},"lang":"en","dir":"ltr","revision":"1268698029","tid":"85f9f58e-cfc6-11ef-a86e-6e709920d10b","timestamp":"2025-01-11T02:48:23Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/AT-076","revisions":"https://en.wikipedia.org/wiki/AT-076?action=history","edit":"https://en.wikipedia.org/wiki/AT-076?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:AT-076"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/AT-076","revisions":"https://en.m.wikipedia.org/wiki/Special:History/AT-076","edit":"https://en.m.wikipedia.org/wiki/AT-076?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:AT-076"}},"extract":"AT-076 is a so-called opioid \"pan\" antagonist and is the first reasonably balanced antagonist known of all four opioid receptor types. It acts as a silent antagonist of all four of the opioid receptors, behaving as a competitive antagonist of the μ-opioid receptor and δ-opioid receptor and as a noncompetitive antagonist of the κ-opioid receptor and nociceptin receptor. AT-076 was derived from the selective κ-opioid receptor antagonist JDTic via removal of the 3,4-dimethyl group of the trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine antagonist scaffold which increased affinity for the nociceptin receptor by 10-fold and for the μ- and δ-opioid receptors by 3-6-fold.","extract_html":"
AT-076 is a so-called opioid \"pan\" antagonist and is the first reasonably balanced antagonist known of all four opioid receptor types. It acts as a silent antagonist of all four of the opioid receptors, behaving as a competitive antagonist of the μ-opioid receptor and δ-opioid receptor and as a noncompetitive antagonist of the κ-opioid receptor and nociceptin receptor. AT-076 was derived from the selective κ-opioid receptor antagonist JDTic via removal of the 3,4-dimethyl group of the trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine antagonist scaffold which increased affinity for the nociceptin receptor by 10-fold and for the μ- and δ-opioid receptors by 3-6-fold.
"}{"slip": { "id": 205, "advice": "Try to not compliment people on things they don't control."}}
{"type":"general","setup":"When a dad drives past a graveyard: Did you know that's a popular cemetery?","punchline":"Yep, people are just dying to get in there","id":50}
{"type":"general","setup":"Where do young cows eat lunch?","punchline":"In the calf-ateria.","id":289}
{"type":"standard","title":"Jacob Palis","displaytitle":"Jacob Palis","namespace":{"id":0,"text":""},"wikibase_item":"Q966663","titles":{"canonical":"Jacob_Palis","normalized":"Jacob Palis","display":"Jacob Palis"},"pageid":1540070,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c2/F%C3%B3rum_Mundial_de_Ci%C3%AAncia_%289361647952%29.jpg/330px-F%C3%B3rum_Mundial_de_Ci%C3%AAncia_%289361647952%29.jpg","width":320,"height":213},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/c/c2/F%C3%B3rum_Mundial_de_Ci%C3%AAncia_%289361647952%29.jpg","width":4193,"height":2795},"lang":"en","dir":"ltr","revision":"1297461475","tid":"85051052-5270-11f0-952f-1631debf4dbe","timestamp":"2025-06-26T09:32:47Z","description":"Brazilian mathematician (1940–2025)","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Jacob_Palis","revisions":"https://en.wikipedia.org/wiki/Jacob_Palis?action=history","edit":"https://en.wikipedia.org/wiki/Jacob_Palis?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Jacob_Palis"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Jacob_Palis","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Jacob_Palis","edit":"https://en.m.wikipedia.org/wiki/Jacob_Palis?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Jacob_Palis"}},"extract":"Jacob Palis Jr. was a Brazilian mathematician and academic. Palis's research interests were mainly dynamical systems and differential equations. Some themes are global stability and hyperbolicity, bifurcations, attractors and chaotic systems. He proposed the Palis' conjectures, which influenced the development of the theory of dynamical systems, and also of its applications to other sciences. He was a world leader in chaos theory research. Palis was an influential figure in the development of mathematics in Brazil.","extract_html":"
Jacob Palis Jr. was a Brazilian mathematician and academic. Palis's research interests were mainly dynamical systems and differential equations. Some themes are global stability and hyperbolicity, bifurcations, attractors and chaotic systems. He proposed the Palis' conjectures, which influenced the development of the theory of dynamical systems, and also of its applications to other sciences. He was a world leader in chaos theory research. Palis was an influential figure in the development of mathematics in Brazil.
"}